USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: SRC_HUMAN USC-OGP 2-DE database:  SRC_HUMAN SRC_HUMAN General information about the entry View entry in simple text format Entry name SRC_HUMAN Primary accession number P12931 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proto-oncogene tyrosine-protein kinase Src; EC=2.7.10.2; AltName: Full=Proto-oncogene c-Src; AltName: Full=pp60c-src; Short=p60-Src;. Gene name Name=SRC Synonyms=SRC1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0667: pI=5.85; Mw=51693 SPOT OGP-0678: pI=5.90; Mw=50174 SPOT OGP-0684: pI=5.85; Mw=47860 Cross-references UniProtKB/Swiss-Prot P12931; SRC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SRC_HUMAN Primary accession number P12931 Secondary accession number(s) E1P5V4 Q76P87 Q86VB9 Q9H5A8 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 216) Name and origin of the protein Description RecName: Full=Proto-oncogene tyrosine-protein kinase Src; EC=2.7.10.2; AltName: Full=Proto-oncogene c-Src; AltName: Full=pp60c-src; Short=p60-Src; Gene name Name=SRC Synonyms=SRC1 Encoded on Name=SRC; Synonyms=SRC1 Keywords 3D-structure; Alternative splicing; ATP-binding; Cell adhesion; Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Host-virus interaction; Immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AL133293; CAC10573.1; -; Genomic_DNA EMBL AL133293; CAC34523.1; -; Genomic_DNA EMBL CH471077; EAW76065.1; -; Genomic_DNA EMBL CH471077; EAW76064.1; -; Genomic_DNA EMBL CH471077; EAW76066.1; -; Genomic_DNA EMBL CH471077; EAW76067.1; -; Genomic_DNA EMBL BC011566; AAH11566.1; -; mRNA EMBL BC051270; AAH51270.2; -; mRNA EMBL K03218; AAA60584.1; -; Genomic_DNA EMBL M16237; AAA60584.1; JOINED; Genomic_DNA EMBL M16243; AAA60584.1; JOINED; Genomic_DNA EMBL M16244; AAA60584.1; JOINED; Genomic_DNA EMBL M16245; AAA60584.1; JOINED; Genomic_DNA EMBL K03212; AAA60584.1; JOINED; Genomic_DNA EMBL K03213; AAA60584.1; JOINED; Genomic_DNA EMBL K03214; AAA60584.1; JOINED; Genomic_DNA EMBL K03215; AAA60584.1; JOINED; Genomic_DNA EMBL K03216; AAA60584.1; JOINED; Genomic_DNA EMBL K03217; AAA60584.1; JOINED; Genomic_DNA EMBL X02647; CAA26485.1; -; Genomic_DNA EMBL X03995; CAA26485.1; JOINED; Genomic_DNA EMBL X03996; CAA26485.1; JOINED; Genomic_DNA EMBL X03997; CAA26485.1; JOINED; Genomic_DNA EMBL X03998; CAA26485.1; JOINED; Genomic_DNA EMBL X03999; CAA26485.1; JOINED; Genomic_DNA EMBL X04000; CAA26485.1; JOINED; Genomic_DNA CCDS CCDS13294.1; -. [P12931-1]; . PIR A26891; TVHUSC; . RefSeq NP_005408.1; NM_005417.4. [P12931-1]; . RefSeq NP_938033.1; NM_198291.2. [P12931-1]; . RefSeq XP_011527315.1; XM_011529013.2. [P12931-1]; . RefSeq XP_016883513.1; XM_017028024.1. [P12931-2]; . RefSeq XP_016883514.1; XM_017028025.1. [P12931-2]; . RefSeq XP_016883515.1; XM_017028026.1. [P12931-2]; . RefSeq XP_016883516.1; XM_017028027.1. [P12931-2]; . UniGene Hs.195659; -; . PDB 1A07; X-ray; 2.20 A; A/B=144-249 PDB 1A08; X-ray; 2.20 A; A/B=144-249 PDB 1A09; X-ray; 2.00 A; A/B=144-249 PDB 1A1A; X-ray; 2.00 A; A/B=144-249 PDB 1A1B; X-ray; 2.20 A; A/B=144-249 PDB 1A1C; X-ray; 2.40 A; A/B=144-249 PDB 1A1E; X-ray; 2.20 A; A/B=144-249 PDB 1FMK; X-ray; 1.50 A; A=86-536 PDB 1HCS; NMR; -; B=144-249 PDB 1HCT; NMR; -; B=144-249 PDB 1KSW; X-ray; 2.80 A; A=86-536 PDB 1O41; X-ray; 1.70 A; A=145-252 PDB 1O42; X-ray; 1.70 A; A=145-252 PDB 1O43; X-ray; 1.50 A; A=145-252 PDB 1O44; X-ray; 1.70 A; A=145-252 PDB 1O45; X-ray; 1.80 A; A=145-252 PDB 1O46; X-ray; 2.00 A; A=145-252 PDB 1O47; X-ray; 1.80 A; A=145-252 PDB 1O48; X-ray; 1.55 A; A=145-252 PDB 1O49; X-ray; 1.70 A; A=145-252 PDB 1O4A; X-ray; 1.50 A; A=145-252 PDB 1O4B; X-ray; 1.85 A; A=145-252 PDB 1O4C; X-ray; 1.80 A; A=145-252 PDB 1O4D; X-ray; 1.85 A; A=145-252 PDB 1O4E; X-ray; 2.00 A; A=145-252 PDB 1O4F; X-ray; 2.00 A; A=145-252 PDB 1O4G; X-ray; 1.55 A; A=145-252 PDB 1O4H; X-ray; 2.25 A; A=145-252 PDB 1O4I; X-ray; 1.75 A; A=145-252 PDB 1O4J; X-ray; 1.70 A; A=145-252 PDB 1O4K; X-ray; 1.57 A; A=145-252 PDB 1O4L; X-ray; 1.65 A; A=145-252 PDB 1O4M; X-ray; 1.60 A; A=145-252 PDB 1O4N; X-ray; 1.60 A; A=145-252 PDB 1O4O; X-ray; 1.70 A; A=145-252 PDB 1O4P; X-ray; 1.90 A; A=145-252 PDB 1O4Q; X-ray; 1.70 A; A=145-252 PDB 1O4R; X-ray; 1.50 A; A=145-252 PDB 1SHD; X-ray; 2.00 A; A=144-249 PDB 1Y57; X-ray; 1.91 A; A=86-536 PDB 1YI6; X-ray; 2.00 A; A/B=261-536 PDB 1YOJ; X-ray; 1.95 A; A/B=254-536 PDB 1YOL; X-ray; 2.30 A; A/B=254-536 PDB 1YOM; X-ray; 2.90 A; A/B=254-536 PDB 2BDF; X-ray; 2.10 A; A/B=258-536 PDB 2BDJ; X-ray; 2.50 A; A=258-536 PDB 2H8H; X-ray; 2.20 A; A=2-536 PDB 2SRC; X-ray; 1.50 A; A=86-536 PDB 3VRO; X-ray; 1.80 A; B=412-424 PDB 3ZMP; X-ray; 2.62 A; C/D=527-536 PDB 3ZMQ; X-ray; 3.30 A; C=527-536 PDB 4F59; X-ray; 1.71 A; A=144-252 PDB 4F5A; X-ray; 1.80 A; A=144-252 PDB 4F5B; X-ray; 1.57 A; A=144-252 PDB 4HXJ; X-ray; 2.00 A; A/B=87-144 PDB 4K11; X-ray; 2.30 A; A=87-534 PDB 4MXO; X-ray; 2.10 A; A/B=254-536 PDB 4MXX; X-ray; 2.60 A; A/B=254-536 PDB 4MXY; X-ray; 2.58 A; A/B=254-536 PDB 4MXZ; X-ray; 2.58 A; A/B=254-536 PDBsum 1A07; -; . PDBsum 1A08; -; . PDBsum 1A09; -; . PDBsum 1A1A; -; . PDBsum 1A1B; -; . PDBsum 1A1C; -; . PDBsum 1A1E; -; . PDBsum 1FMK; -; . PDBsum 1HCS; -; . PDBsum 1HCT; -; . PDBsum 1KSW; -; . PDBsum 1O41; -; . PDBsum 1O42; -; . PDBsum 1O43; -; . PDBsum 1O44; -; . PDBsum 1O45; -; . PDBsum 1O46; -; . PDBsum 1O47; -; . PDBsum 1O48; -; . PDBsum 1O49; -; . PDBsum 1O4A; -; . PDBsum 1O4B; -; . PDBsum 1O4C; -; . PDBsum 1O4D; -; . PDBsum 1O4E; -; . PDBsum 1O4F; -; . PDBsum 1O4G; -; . PDBsum 1O4H; -; . PDBsum 1O4I; -; . PDBsum 1O4J; -; . PDBsum 1O4K; -; . PDBsum 1O4L; -; . PDBsum 1O4M; -; . PDBsum 1O4N; -; . PDBsum 1O4O; -; . PDBsum 1O4P; -; . PDBsum 1O4Q; -; . PDBsum 1O4R; -; . PDBsum 1SHD; -; . PDBsum 1Y57; -; . PDBsum 1YI6; -; . PDBsum 1YOJ; -; . PDBsum 1YOL; -; . PDBsum 1YOM; -; . PDBsum 2BDF; -; . PDBsum 2BDJ; -; . PDBsum 2H8H; -; . PDBsum 2SRC; -; . PDBsum 3VRO; -; . PDBsum 3ZMP; -; . PDBsum 3ZMQ; -; . PDBsum 4F59; -; . PDBsum 4F5A; -; . PDBsum 4F5B; -; . PDBsum 4HXJ; -; . PDBsum 4K11; -; . PDBsum 4MXO; -; . PDBsum 4MXX; -; . PDBsum 4MXY; -; . PDBsum 4MXZ; -; . ProteinModelPortal P12931; -; . SMR P12931; -; . BioGrid 112592; 262; . DIP DIP-1059N; -; . IntAct P12931; 191; . MINT MINT-93621; -; . STRING 9606.ENSP00000350941; -; . BindingDB P12931; -; . ChEMBL CHEMBL267; -; . DrugBank DB08564; (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; . DrugBank DB06882; 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea; . DrugBank DB06883; 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea; . DrugBank DB08192; 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE; . DrugBank DB04739; 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE; . DrugBank DB07966; [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile; . DrugBank DB06616; Bosutinib; . DrugBank DB04272; Citric Acid; . DrugBank DB01254; Dasatinib; . DrugBank DB03217; DPI59; . DrugBank DB03628; ISO24; . DrugBank DB02175; Malonic acid; . DrugBank DB08462; N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE; . DrugBank DB07662; N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE; . DrugBank DB01893; N6-Benzyl Adenosine-5'-Diphosphate; . DrugBank DB09079; Nintedanib; . DrugBank DB03902; Oxalic Acid; . DrugBank DB03114; PAS219; . DrugBank DB03078; PASBN; . DrugBank DB03298; Phenylphosphate; . DrugBank DB01962; Phosphonotyrosine; . DrugBank DB08901; Ponatinib; . DrugBank DB04751; Purvalanol A; . DrugBank DB04080; RU78191; . DrugBank DB01947; RU78262; . DrugBank DB03828; RU78299; . DrugBank DB03306; RU78300; . DrugBank DB02908; RU78783; . DrugBank DB02762; RU79072; . DrugBank DB03525; RU79073; . DrugBank DB01866; RU79256; . DrugBank DB04495; RU81843; . DrugBank DB03104; RU82129; . DrugBank DB03268; RU82197; . DrugBank DB03591; RU82209; . DrugBank DB02336; RU83876; . DrugBank DB01678; RU84687; . DrugBank DB03712; RU85053; . DrugBank DB01908; RU85493; . DrugBank DB02432; RU90395; . DrugBank DB05184; XL228; . GuidetoPHARMACOLOGY 2206; -; . iPTMnet P12931; -; . PhosphoSitePlus P12931; -; . SwissPalm P12931; -; . DMDM 125711; -; . OGP P12931; -; . EPD P12931; -; . MaxQB P12931; -; . PaxDb P12931; -; . PeptideAtlas P12931; -; . PRIDE P12931; -; . DNASU 6714; -; . Ensembl ENST00000358208; ENSP00000350941; ENSG00000197122. [P12931-1]; . Ensembl ENST00000373558; ENSP00000362659; ENSG00000197122. [P12931-2]; . Ensembl ENST00000373567; ENSP00000362668; ENSG00000197122. [P12931-1]; . Ensembl ENST00000373578; ENSP00000362680; ENSG00000197122. [P12931-1]; . GeneID 6714; -; . KEGG hsa:6714; -; . UCSC uc002xgy.5; human. [P12931-1]; . CTD 6714; -; . DisGeNET 6714; -; . GeneCards SRC; -; . HGNC HGNC:11283; SRC; . HPA CAB004023; -; . HPA HPA030875; -; . MalaCards SRC; -; . MIM 190090; gene; . MIM 616937; phenotype; . neXtProt NX_P12931; -; . OpenTargets ENSG00000197122; -; . PharmGKB PA36111; -; . eggNOG KOG0197; Eukaryota; . eggNOG COG0515; LUCA; . GeneTree ENSGT00760000118938; -; . HOGENOM HOG000233858; -; . HOVERGEN HBG008761; -; . InParanoid P12931; -; . KO K05704; -; . OMA CQCWRKD; -; . OrthoDB EOG091G0D46; -; . PhylomeDB P12931; -; . TreeFam TF351634; -; . BioCyc MetaCyc:HS02256-MONOMER; -; . BRENDA 2.7.10.2; 2681; . Reactome R-HSA-1227986; Signaling by ERBB2; . Reactome R-HSA-1295596; Spry regulation of FGF signaling; . Reactome R-HSA-1433557; Signaling by SCF-KIT; . Reactome R-HSA-1433559; Regulation of KIT signaling; . Reactome R-HSA-171007; p38MAPK events; . Reactome R-HSA-177929; Signaling by EGFR; . Reactome R-HSA-180292; GAB1 signalosome; . Reactome R-HSA-186763; Downstream signal transduction; . Reactome R-HSA-191647; c-src mediated regulation of Cx43 function and closure of gap junctions; . Reactome R-HSA-2029481; FCGR activation; . Reactome R-HSA-210990; PECAM1 interactions; . Reactome R-HSA-2682334; EPH-Ephrin signaling; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-375165; NCAM signaling for neurite out-growth; . Reactome R-HSA-389356; CD28 co-stimulation; . Reactome R-HSA-389513; CTLA4 inhibitory signaling; . Reactome R-HSA-391160; Signal regulatory protein (SIRP) family interactions; . Reactome R-HSA-3928662; EPHB-mediated forward signaling; . Reactome R-HSA-3928663; EPHA-mediated growth cone collapse; . Reactome R-HSA-3928664; Ephrin signaling; . Reactome R-HSA-3928665; EPH-ephrin mediated repulsion of cells; . Reactome R-HSA-418592; ADP signalling through P2Y purinoceptor 1; . Reactome R-HSA-418885; DCC mediated attractive signaling; . Reactome R-HSA-418886; Netrin mediated repulsion signals; . Reactome R-HSA-430116; GP1b-IX-V activation signalling; . Reactome R-HSA-437239; Recycling pathway of L1; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs); . Reactome R-HSA-5218921; VEGFR2 mediated cell proliferation; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-8853659; RET signaling; . Reactome R-HSA-8874081; MET activates PTK2 signaling; . Reactome R-HSA-8876493; InlA-mediated entry of Listeria monocytogenes into host cells; . SignaLink P12931; -; . SIGNOR P12931; -; . ChiTaRS SRC; human; . EvolutionaryTrace P12931; -; . GeneWiki Src_(gene); -; . GenomeRNAi 6714; -; . PMAP-CutDB P12931; -; . PRO PR:P12931; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000197122; -; . CleanEx HS_SRC; -; . Genevisible P12931; HS; . GO GO:0005884; C:actin filament; IEA:Ensembl; . GO GO:0005901; C:caveola; IDA:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central; . GO GO:0005770; C:late endosome; IDA:UniProtKB; . GO GO:0005764; C:lysosome; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043005; C:neuron projection; IEA:Ensembl; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0002102; C:podosome; IEA:Ensembl; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0032587; C:ruffle membrane; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0046875; F:ephrin receptor binding; IPI:UniProtKB; . GO GO:0070851; F:growth factor receptor binding; IPI:UniProtKB; . GO GO:0020037; F:heme binding; IDA:UniProtKB; . GO GO:0051427; F:hormone receptor binding; IBA:GO_Central; . GO GO:0005178; F:integrin binding; TAS:BHF-UCL; . GO GO:0044325; F:ion channel binding; IPI:BHF-UCL; . GO GO:0016301; F:kinase activity; TAS:Reactome; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:BHF-UCL; . GO GO:0051219; F:phosphoprotein binding; IPI:UniProtKB; . GO GO:0004672; F:protein kinase activity; IDA:UniProtKB; . GO GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB; . GO GO:0005102; F:receptor binding; IPI:UniProtKB; . GO GO:0097110; F:scaffold protein binding; IPI:BHF-UCL; . GO GO:0042169; F:SH2 domain binding; IPI:UniProtKB; . GO GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc; . GO GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl; . GO GO:0034332; P:adherens junction organization; IEA:Ensembl; . GO GO:0086098; P:angiotensin-activated signaling pathway involved in heart process; ISS:BHF-UCL; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0045453; P:bone resorption; ISS:UniProtKB; . GO GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl; . GO GO:0007049; P:cell cycle; IEA:UniProtKB-KW; . GO GO:0008283; P:cell proliferation; IEA:Ensembl; . GO GO:0071398; P:cellular response to fatty acid; IEA:Ensembl; . GO GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl; . GO GO:0071456; P:cellular response to hypoxia; IEA:Ensembl; . GO GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl; . GO GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl; . GO GO:0071375; P:cellular response to peptide hormone stimulus; ISS:BHF-UCL; . GO GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl; . GO GO:0071393; P:cellular response to progesterone stimulus; ISS:BHF-UCL; . GO GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl; . GO GO:0007417; P:central nervous system development; IBA:GO_Central; . GO GO:0035635; P:entry of bacterium into host cell; TAS:Reactome; . GO GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central; . GO GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0030900; P:forebrain development; IEA:Ensembl; . GO GO:0045087; P:innate immune response; IBA:GO_Central; . GO GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB; . GO GO:0030520; P:intracellular estrogen receptor signaling pathway; IBA:GO_Central; . GO GO:0035556; P:intracellular signal transduction; IDA:BHF-UCL; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:2000811; P:negative regulation of anoikis; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB; . GO GO:0051895; P:negative regulation of focal adhesion assembly; ISS:BHF-UCL; . GO GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB; . GO GO:0051902; P:negative regulation of mitochondrial depolarization; IMP:UniProtKB; . GO GO:0032463; P:negative regulation of protein homooligomerization; IMP:UniProtKB; . GO GO:0051974; P:negative regulation of telomerase activity; IMP:BHF-UCL; . GO GO:0032211; P:negative regulation of telomere maintenance via telomerase; IMP:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IEA:Ensembl GO GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl; . GO GO:0048477; P:oogenesis; IEA:Ensembl; . GO GO:0036035; P:osteoclast development; IBA:GO_Central; . GO GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl; . GO GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central; . GO GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IBA:GO_Central; . GO GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl; . GO GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl; . GO GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl; . GO GO:2000573; P:positive regulation of DNA biosynthetic process; IEA:Ensembl; . GO GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl; . GO GO:0010907; P:positive regulation of glucose metabolic process; IEA:Ensembl; . GO GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl; . GO GO:0033625; P:positive regulation of integrin activation; TAS:BHF-UCL; . GO GO:2000394; P:positive regulation of lamellipodium morphogenesis; IMP:UniProtKB; . GO GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl; . GO GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IC:UniProtKB; . GO GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl; . GO GO:0010641; P:positive regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl; . GO GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl; . GO GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Ensembl; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IMP:UniProtKB; . GO GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl; . GO GO:0010954; P:positive regulation of protein processing; IEA:Ensembl; . GO GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:UniProtKB; . GO GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IMP:ParkinsonsUK-UCL; . GO GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IEA:Ensembl GO GO:0050847; P:progesterone receptor signaling pathway; ISS:BHF-UCL; . GO GO:0046777; P:protein autophosphorylation; IDA:UniProtKB; . GO GO:0031648; P:protein destabilization; IEA:Ensembl; . GO GO:0045124; P:regulation of bone resorption; TAS:BHF-UCL; . GO GO:2001286; P:regulation of caveolin-mediated endocytosis; IMP:UniProtKB; . GO GO:0051726; P:regulation of cell cycle; IBA:GO_Central; . GO GO:0060491; P:regulation of cell projection assembly; IEA:Ensembl; . GO GO:0042127; P:regulation of cell proliferation; IBA:GO_Central; . GO GO:0022407; P:regulation of cell-cell adhesion; IMP:UniProtKB; . GO GO:2000641; P:regulation of early endosome to late endosome transport; IMP:UniProtKB; . GO GO:0010632; P:regulation of epithelial cell migration; IMP:UniProtKB; . GO GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl; . GO GO:0071801; P:regulation of podosome assembly; IBA:GO_Central; . GO GO:0043393; P:regulation of protein binding; IEA:Ensembl; . GO GO:0043114; P:regulation of vascular permeability; TAS:BHF-UCL; . GO GO:0010447; P:response to acidic pH; IEA:Ensembl; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0051602; P:response to electrical stimulus; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; . GO GO:0070555; P:response to interleukin-1; IMP:BHF-UCL; . GO GO:0009612; P:response to mechanical stimulus; IEA:Ensembl; . GO GO:0051385; P:response to mineralocorticoid; IEA:Ensembl; . GO GO:0031667; P:response to nutrient levels; IEA:Ensembl; . GO GO:0009615; P:response to virus; IEA:Ensembl; . GO GO:0007172; P:signal complex assembly; TAS:ProtInc; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . GO GO:0016337; P:single organismal cell-cell adhesion; IEA:Ensembl; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0043149; P:stress fiber assembly; IMP:UniProtKB; . GO GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0045056; P:transcytosis; IEA:Ensembl; . GO GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB; . GO GO:0060065; P:uterus development; IEA:Ensembl; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 3.30.505.10; -; 1; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR001245; Ser-Thr/Tyr_kinase_cat_dom; . InterPro IPR000980; SH2; . InterPro IPR001452; SH3_domain; . InterPro IPR008266; Tyr_kinase_AS; . InterPro IPR020635; Tyr_kinase_cat_dom; . Pfam PF07714; Pkinase_Tyr; 1; . Pfam PF00017; SH2; 1; . Pfam PF00018; SH3_1; 1; . PRINTS PR00401; SH2DOMAIN; . PRINTS PR00452; SH3DOMAIN; . PRINTS PR00109; TYRKINASE; . SMART SM00252; SH2; 1; . SMART SM00326; SH3; 1; . SMART SM00219; TyrKc; 1; . SUPFAM SSF50044; SSF50044; 1; . SUPFAM SSF55550; SSF55550; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00109; PROTEIN_KINASE_TYR; 1; . PROSITE PS50001; SH2; 1; . PROSITE PS50002; SH3; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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